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A difference is metronidazole is taken orally and clindamycin phosphate vaginal cream is used topically (on the skin) Metronidazole and fluconazole are used to treat different types of vaginal infections. A difference is metronidazole is taken orally and azelaic acid is used topically (on the skin) Metronidazole (Flagyl) and clindamycin (Cleocin) phosphate vaginal cream are antibiotics used to treat vaginal infections. ...

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