Ov/medwatch. Tolterodine (detrol) pkge. 1 mg 10 amount of packaging.
3 at pH 7. The partition coefficient Log D between n-octanol and water is 1.
Cardiomyopathy, myocardial ischaemia, arrhythmia, congestive heart failure Concomitant administration of drugs known to prolong QT-interval including Class IA e. quinidine, procainamide and Class III e.
Tolterodine should be used what is tolterodine tartrate caution in patients with what is tolterodine tartrate factors for QT-prolongation including: Relevant pre-existing cardiac diseases i. g.
There has been no association of Torsade de Pointes in the international post-marketing experience with tolterodine tartrate tablets or tolterodine tartrate extended-release capsules 14C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, tolterodine tartrate tablets least 77% of the radiolabeled dose was absorbed. Tolterodine is extensively metabolized by the liver following oral dosing. This study was not designed to make direct statistical comparisons between drugs or dose levels.
C min levels of tolterodine extended-release are about 75% and 150% of tolterodine immediate release, respectively. Tolterodine tartrate tablets serum concentrations of tolterodine extended-release are observed 2 to 6 hours after dose administration. tolterodine tartrate tablets
Tolterodine tartrate tablets
6 or 5. 4 msec increase from baseline as measured by machine or manually, respectively than a dosage of 2 mg twice daily 1.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. What is tolterodine tartrate both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Tolterodine alternative names goods:
- Breminal 2 mg
- Detrusitol 2 mg
- Tolorin 2 mg
- Toltem 1 mg
- Tolter 2 mg
- Tolterodin 2 mg
- Tolterodina 2 mg
- Toltérodine 2 mg
- Tolterodinum 2 mg
- Toltex 1 mg
- Ucol 2 mg
- Urginol 1 mg
- Uroflow 2 mg
- Urotrol 2 mg
Medline. Br J Obstet Gynaecol. 1990 Jun. -6.
Chapple, C. et al. BJU International. Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase 2 dose-finding study. 03-310. tolterodine tartrate 2mg tab
305Renal organic cation transporterInhibitor0. 904CYP450 2C9 substrateNon-substrate0. 727P-glycoprotein inhibitor IINon-inhibitor0. 235CYP450 2D6 substrateSubstrate0. 918CYP450 3A4 substrateSubstrate0. P-glycoprotein inhibitor INon-inhibitor0.
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Tolterodine tartrate er capsules
Other medicines can affect how your body handles tolterodine. This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. The FDA categorizes medications based on safety for use during pregnancy.
Five categories - A, B, C, D, and X, are tolterodine tartrate er capsules to classify the possible risks to an unborn baby when a medication is taken during pregnancy with celexa acid reflux. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.
Your doctor may use a lower dose of tolterodine if you are taking: Certain medicines for fungus or yeast infectionsCertain medicines for bacterial infectionsSandimmune cyclosporine or Velban vinblastine Tell your doctor if you are pregnant or plan to become pregnant. tolterodine tartrate er capsules
Tolterodine tartrate 4mg Int Urogynecol J. p. Milani, R. et al. Double-blind crossover comparison of flavoxate and oxybutynin in women affected by urinary-urge syndrome.
|The mean AUC of tolterodine was 6.||Tolterodine tartrate 4mg tolterodine tartrate 4mg You can also call Mylan at 1-877-446-3679 (1-877-4-INFO-RX) What are the ingredients in tolterodine tartrate extended-release capsules? You can ask your doctor or pharmacist for information about tolterodine tartrate extended-release capsules that is written for health professionals.||382. ISBN. tolterodine tartrate 4mg|
|With that, I have seen it affect my menstrual cycle.||Tolterodine tartrate er capsules International Urology Nephrology.||What is tolterodine tartrate 5. The mean exposure of the active moiety per mg dose is approximately 2-fold higher in children between 5 10 years than in adults (see section 4.|
|Tolterodine tartrate er capsules Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue.||If you miss a dose of tolterodine, take it as tolterodine tartrate 4mg as possible. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. tolterodine tartrate 4mg||Tolterodine tartrate 4mg of pediatric patients receiving tolterodine extended-release capsules compared with 0. Aggressive, abnormal, and hyperactive behavior and attention disorders were reported in 2.|
What is tolterodine tartrate
If you have questions or concerns about the substances you are taking, check with your healthcare what is tolterodine tartrate. The absence of a warning or notice for a given drug or drug combination is not indication that the drug or drug combination are safe, appropriate or effective for any what is tolterodine tartrate patient.
To 2. In animal reproduction studies, oral administration of tolterodine and its 5-HMT metabolite to pregnant mice during organogenesis did not produce adverse developmental outcomes at doses approximately 9 to 12 times the clinical exposure at tolterodine tartrate 2mg tab dose of 20 mg/kg/day; however, higher doses produced adverse developmental outcomes In the U.
general population, the estimated background rate of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20% respectively. No anomalies or malformations were observed after oral administration of tolterodine to pregnant mice during organogenesis at approximately 9 to 12 times the clinical exposure to the pharmacologically active components of tolterodine tartrate extended-release capsules based on the AUC of tolterodine and its 5-HMT metabolite at a tolterodine tartrate tablets of 20 mg/kg/day At 14 to 18 times the clinical exposure doses of 30 to 40 mg/kg/day in mice, tolterodine tartrate 2mg tab was embryo-lethal, caused reduced fetal weight, and increased the incidence of fetal abnormalities cleft palate, digital abnormalities, intra-abdominal hemorrhage, and various skeletal abnormalities, primarily reduced ossification Pregnant rabbits administered tolterodine subcutaneously at about 0.
- Tolterodine all alternative name: breminal, detrusitol, tolorin, toltem, tolter, tolterodin, tolterodina, toltérodine, tolterodinum, toltex, ucol, urginol, uroflow, urotrol
- Active substance: detrol
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Tolterodine tartrate 4mg
Finally figured out that it correlated to when I started on the Detrol LA. I ve called tolterodine tartrate 4mg asked to switch to another medicine. Detrol tolterodine Before using Detrol I was up 2-4 times a night to urinate, plus there was severe urgency. fter taking Detrol for a little over a week, all of these conditions tolterodine tartrate 4mg. I can t function this way. I have had a terrible head-ache, fatigue, and just felt awful.
Therefore, Tolterodine tartrate is not recommended for children. known hypersensitivity to tolterodine tartrate or to any of the excipients Multiple oral total daily doses of immediate release 4 mg therapeutic what is tolterodine tartrate 8 what is tolterodine tartrate supratherapeutic tolterodine have been shown to prolong the QTc interval see section 5. The clinical relevance of these findings is unclear and will depend on individual patient risk factors and susceptibilities present.
Efficacy of Tolterodine tartrate has not been demonstrated in children see section 5.
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Will the sleepiness from tolterodine tart wear off?
DETROL LA 4 mg was evaluated for the tolterodine tartrate 4mg of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, 12 week study. 5 M while tolterodine immediate release as well as the 5-HMT are devoid of any significant DETROL LA Capsules 2 mg were evaluated in 29 patients in a Phase 2 dose-effect study.
In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, Tolterodine tartrate 4mg, and omeprazole. In vitro data show that tolterodine immediate release is a competitive inhibitor of CYP2D6 at high concentrations K 1.
What is tolterodine medicine used for?
If both medicines are prescribed together, your doctor may change what is tolterodine tartrate dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
What best reflects the action of tolterodine?
While safety and efficacy of tolterodine tartrate in geriatric patients have not been studied specifically, several hundred patients receiving the drug in clinical studies were 65-91 years of age.
Although in one phase I clinical study higher serum concentrations of tolterodine and its 5-hydroxymethyl metabolite were reported in healthy geriatric individuals 71-81 years of age compared with those reported in young healthy adults, overall differences in safety were not what is tolterodine tartrate between geriatric and younger patients.
of those receiving placebo.
Are toviaz and tolterodine in the same class of medication?
And 1. with tolterodine tartrate 1 mg twice daily, tolterodine tartrate 2 mg twice daily, and placebo, respectively Tolterodine tartrate dosages of 1 or 2 mg twice daily as conventional tablets appear to have similar efficacy concerning number of micturitions per 24 hours, episodes of incontinence, and volume of urine voided per micturition. respectively However, analysis of pooled data that excluded patients with no episodes of incontinence at baseline from several studies of tolterodine tartrate 2mg tab weeks' duration indicate that tolterodine tartrate 2mg tab therapy was associated with a statistically significant decrease in the mean number of episodes of incontinence per 24 hours compared with placebo.
Is tolterodine an anticholinergic?
However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, 12-week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended. In multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of 5-HMT tolterodine tartrate tablets similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years In another tolterodine tartrate tablets study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid Mean serum concentrations of tolterodine and 5-HMT in these elderly volunteers were approximately 20% and 50% higher, respectively, than concentrations reported in young healthy volunteers.
The effectiveness of tolterodine tartrate extended-release capsules has not been established in pediatric patients. No overall differences in safety were observed between tolterodine tartrate tablets older and younger patients treated with tolterodine.
Is tolterodine a prodrug?
Beats/minute. The reason for the difference between machine and manual read of QT interval is unclear. The change in heart rate with moxifloxacin was 0.
Does tolterodine cause rash?
Contact Pfizer RxPathways for details 844-989-7284 Applicable drugs: Detrol LA tolterodine tartrate Capsule; Extended Release More information please phone: 866-706-2400 Visit Website Drugs. om provides accurate and independent information on more than 24, 00 prescription drugs, over-the-counter medicines and natural products. Contact Pfizer RxPathways for details 844-989-7284 Applicable drugs: Detrol LA tolterodine tartrate Capsule; Extended Release More information please phone: 866-706-2400or 855-239-9869 Visit Website Elligibility requirements: Uninsured or UnderinsuredVariesNot specifiedMust be residing in the US or US territoryPfizer also has programs that provide eligible tolterodine tartrate er capsules withinsurance, support assistance, and medicines at a savings.
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What is tolterodine pills used for?
Tolterodine should be avoided during lactation. onsequently, Detrusitol is not recommended during pregnancy. Due to the pharmacological effect of tolterodine it may cause mild to moderate antimuscarinic effects, like dryness of the mouth, dyspepsia and dry eyes.
actationNo data concerning the tolterodine tartrate tablets of tolterodine into human milk are available.
Does tolterodine cause water retention?
Tolterodine has a pronounced effect on bladder function. 5-HMT, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels.
What population is tolterodine used to treat?
Further metabolism leads to formation of the 5-carboxylic acid and N-dealkylated 5-carboxylic acid metabolites, which account for 51% and 29% of the metabolites recovered in the urine, respectively. The primary metabolic what is tolterodine tartrate is mediated by the polymorphic enzyme CYP2D6 and leads to the formation of the 5-hydroxymethyl metabolite.
Is tolterodine safe?
Efficacy or safety of Detrol in the pediatric population has not been demonstrated. It is unknown if Tolterodine tartrate tablets passes into breast milk.
Our Detrol tolterodine tartrate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Tolterodine tartrate tablets who are thinking about breastfeeding or are breastfeeding should not breastfeed while taking Detrol, or discontinue taking the medication.
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Reviews tolterodine; 5 counts:
Tolterodine tartrate tablets tolterodine tartrate tablets hat happened twice and while at my doctor s office for a routine visit I consulted with him. e sent me home with a seven day sample of Detrol LA 4mg capsules. Detrol LA seems to be the best of the two. Detrol LA tolterodine I could make it to the bathroom door, but could not even get into the bathroom when there was a small leakage of urine.
Slight improvement but dizziness re-started.
And tolterodine IR 2 mg twice daily P. The median reduction in these episodes tolterodine tartrate er capsules a percentage of the baseline values was 71% for tolterodine ER, 60% for tolterodine IR, and 33% for placebo. Tolterodine ER 4 mg once daily P. The ER formulation was 18% more effective than the IR formulation P 0. both significantly reduced the mean number of urge incontinence episodes per week compared with tolterodine tartrate er capsules
However, in one what is tolterodine tartrate study in which cystometry was used to evaluate outcomes, only the 2-mg dosage was more effective than placebo in increasing the volume at first contraction and the maximum cystometric capacity, although both dosages increased the residual volume compared with placebo.
with tolterodine tartrate 1 mg twice what is tolterodine tartrate, tolterodine tartrate 2 mg twice daily, and placebo, respectively Tolterodine tartrate dosages of 1 or 2 mg twice daily as conventional tablets appear to have similar efficacy concerning number of micturitions per 24 hours, episodes of incontinence, and volume of urine voided per micturition. what is tolterodine tartrate
Many people using this medication do not have serious side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling especially of the face/tongue/throat severe dizziness, trouble breathing. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Tell your doctor right away if you have any serious side effects, including: vision changes, severe stomach/abdominal pain, trouble urinating, signs of kidney infection such as tolterodine tartrate tablets urination, lower back pain, tolterodine tartrate tablets Get tolterodine tartrate tablets help right away if you have any very serious side effects, including: fast/slow/irregular heartbeat, severe dizziness, fainting.
A very serious allergic reaction to this drug is rare.
Carton of 30 tablets 10 tablets each blister pack x 3 NDC 0904-6593-04 This drug label information is as submitted to the Food and Drug Administration FDA and is intended for informational purposes only. Carton of 30 tablets 10 tablets each blister pack x 3 NDC 0904-6592-04 4 mg capsules are size "3", hard gelatin capsules having a blue cap and tolterodine tartrate 4mg body, imprinted "1190" on the tolterodine tartrate 4mg with white ink, containing off-white to brownish colored pellets. tolterodine tartrate 4mg