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Data presented are mean (SD) or n (% ACEi angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, BB beta-blocker, CAD coronary artery disease, CCB calcium channel blocker, CCS Canadian Cardiovascular Society, DBP diastolic blood pressure, LAN long-acting nitrates, SBP systolic blood pressure, SD standard deviation In the Safety Set (which consisted of all the randomized and treated patients, i. Vastarel packing 20 mg 10 the amount of packaging.

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Heart rate bpm. BP mmHg.

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PMC free article PubMed Google Scholar 22. Detry JM, Sellier P, Pennaforte S, et al. Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group. Am J Cardiovasc Drugs.

Evaluation of the myocardial protection of trimetazidine during percutaneous coronary intervention: a multi-center randomized and controlled clinical study. Chen JD, Zhao LK, Tian F, et al.

BP mmHg. lood pressure SBP mmHg.

Effects of trimetazidine on heart rate variability and left ventricular systolic performance in patients with coronary artery disease after percutaneous transluminal angioplasty. Angiology. bMed Google Scholar 38. Zhonghua Yi Xue Za Zhi. ubMed Google Scholar 37. Birand A, Kudaiberdieva Vastarel 60 mg, Batyraliev TA, vastarel 60 mg al.

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Effects of trimetazidine on heart rate variability and left ventricular systolic performance in patients with coronary artery disease after percutaneous transluminal angioplasty. Angiology. Birand A, Kudaiberdieva GZ, Batyraliev TA, et vastarel mr 35 mg

Simon N, Brunet P, Roumenov D, et al. The effects what is vastarel tablets used for trimetazidine-cyclosporin a coadministration on interleukin 2 and cyclosporin a blood levels in renal transplant patients.

Eur J Drug Metab Pharmacokinet. 1 68. Therapie. ubMed Google Scholar 10.

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Vastarel indication Vastarel indication J Cardiovasc Drugs. Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study TRIMPOL II TRIMetazidine in Poland. bMed Google Scholar 29. Eur Heart J. Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.

Clin Cardiol. Cardiology. Efficacy comparison of trimetazidine with therapeutic alternatives in what is vastarel tablets used for angina pectoris: a network meta-analysis. PMC free article PubMed Google Scholar 24. Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials. Danchin N, Marzilli M, Parkhomenko A, et al.

  • Vastarel tablet Your heart is a muscle that receives its supply of oxygenated blood and nutrients from your coronary arteries. Vastarel MR allows you relief from the symptoms of angina as well as providing cytoprotective action during ischemia. vastarel tablet vastarel tablet
  • UbMed Google Scholar 42. Effect of trimetazidine on recurrent angina pectoris and left ventricular structure in elderly multivessel coronary heart disease patients with vastarel tablet mellitus after drug-eluting stent implantation: a single-centre, prospective, randomized, vastarel tablet study vastarel tablet 2-year follow-up. Clin Drug Investig.
  • Presse Med. ubMed Google Scholar 26. Szwed H, Sadowski Z, Elikowski W, et al. TRIMPOL I, a vastarel 60 mg study.
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  • Trimetazidine in Angina Combination Therapy the TACT vastarel tablet trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter study. Am J Ther. Chazov EI, Lepakchin VK, Zharova EA, et al. vastarel tablet

Vastarel mr 35 mg indication When oxygen is in low supply, the oxidative processes of FFA and glucose are disrupted paradoxically leading to an increased rate of FFA -oxidation associated with even greater oxygen consumption while glucose metabolism decreases, which results in lactate vastarel mr 35 mg indication and, in extreme cases, development of metabolic acidosis1, 2.

The best known trimetazidine mechanism of action is its capacity to inhibit -oxidation of free fatty acid FFA FFA oxidation provides more energy, but it is associated with increased oxygen consumption.

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There is scarce information about trimetazidine's effect on mortality, cardiovascular events or quality of life. 5 Trimetazidine has been treated as a drug with a high safety and tolerability what is vastarel tablets used for. 6 It interacts with monoamine oxidase inhibitors.

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UbMed Google Scholar 8. Biopharm Drug Dispos.

Trimetazidine what is vastarel tablets used for left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study. ubMed Google Scholar 42. Cardiovasc Diabetol. 9. Rosano GM, Vitale C, Sposato B, et al.

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    As a precautionary measure, it is preferable to avoid the use of Trimetazidine during pregnancy. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity.

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    Cardiovasc Drugs Ther. The antiischemic effects and tolerability of trimetazidine in coronary diabetic patients. A substudy from TRIMPOL-1.

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    A risk to vastarel tablet newborns/infants cannot be excluded. It is unknown whether Trimetazidine is excreted in human milk.

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    Br J Clin Pharmacol. Trimetazidine European Multicenter Study Group.

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    Vastarel MR allows you relief from the symptoms of angina as well as providing cytoprotective action during ischemia. Your heart is a muscle that receives its supply of oxygenated blood and nutrients from your coronary arteries.

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    Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Tuunanen H, Engblom E, Naum A, et al. Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery vastarel 60 mg.

    Eur Heart J. ubMed Google Scholar 44.

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    In 2012 European Medicines Agency (EMA) finished a review of benefits and risks of trimetazidine and recommended restricting use of trimetazidine-containing medicines just as an additional treatment of angina pectoris in case of inadequate control by or intolerance to first-line antianginal therapies. It is taken twice a day. ...