Breast-feeding while using this drug is not recommended. Vytorin (ezetimibe) pack 20 mg 30 the amount of packaging.
Cholesterol medicine vytorin Comparable reductions in LDL-cholesterol concentrations were observed in the subgroup of patients with cholesterol medicine vytorin homozygous familial hypercholesterolemia. Beneficial effects of ezetimibe combined with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia who currently are undergoing LDL apheresis compared with effects in patients not undergoing the procedure have not been established.
In this study, patients were randomized to receive 1 of 3 regimens: atorvastatin 80 mg daily or simvastatin 80 mg daily monotherapy; ezetimibe 10 mg daily with cholesterol medicine vytorin atorvastatin 40 mg daily or simvastatin 40 mg daily or ezetimibe 10 mg daily with either atorvastatin 80 mg daily or simvastatin 80 mg daily The addition of ezetimibe 10 mg cholesterol medicine vytorin to therapy with atorvastatin 40 or 80 mg daily or simvastatin 40 or 80 mg daily was more effective in reducing LDL-cholesterol concentrations 21% additional reduction based on pooled data from 40-mg and 80-mg groups than increasing the dosage of atorvastatin or simvastatin monotherapy from 40 to 80 mg daily 7% cholesterol medicine vytorin reduction based on pooled data from 40-mg and 80-mg groups In the entire group of patients receiving higher dosages 80 mg daily of either atorvastatin or simvastatin in cholesterol medicine vytorin with ezetimibe 10 mg daily LDL-cholesterol concentrations were reduced by approximately 27% compared with a 7% reduction with statin monotherapy.
Efficacy and safety of ezetimibe combined with atorvastatin or simvastatin for the management of homozygous familial hypercholesterolemia were established in a randomized, double-blind cholesterol medicine vytorin of 12 weeks' duration in a limited number of patients with a clinical and/or genotypic diagnosis of homozygous familial hypercholesterolemia who were already receiving atorvastatin 40 mg daily or simvastatin 40 mg daily with or without concomitant LDL apheresis.
-fold respectively. -fold range 3. - to 4.
Your pharmacist can provide more information about ezetimibe and simvastatin. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. vytorin colesterol information contained herein vytorin colesterol be time sensitive.
ultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
ultum's drug information does not endorse drugs, diagnose patients or recommend therapy. Not all possible drug interactions are listed here. vytorin colesterol
See the end of this leaflet for a complete list of ingredients in Vytorin. HIV protease inhibitors indinavir, nelfinavir, ritonavir, saquinavir, tipranavir, or atazanavir Certain hepatitis C virus protease inhibitors such as boceprevir or telaprevir Ask your doctor or pharmacist for a list of these medicines if you are not sure.
are pregnant or plan to become pregnant. are allergic to ezetimibe cholesterol medicine vytorin simvastatin or any of the ingredients in Vytorin.
Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. cholesterol medicine vytorinVytorin alternative name goods:
- Acotral 20 mg
- Afordel 30 mg
- Alcosin 20 mg
- Alipas 30 mg
- Alpheus 20 mg
- Angiolip 30 mg
- Antichol 30 mg
- Arudel 20 mg
- Astax 30 mg
- Aterostat 20 mg
- Athenil 20 mg
- Atorvik-ez 30 mg
- Avastin 30 mg
- Awestatin 20 mg
- Belmalip 20 mg
- Bevostatin 30 mg
- Cardin 20 mg
- Cerclerol 20 mg
- Cholemed 30 mg
- Cholestad 30 mg
Drug therapy is indicated as an adjunct to diet vytorin colesterol the response to vytorin colesterol diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate. Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia.
Use of ezetimibe in combination with simvastatin dosages exceeding 40 mg daily has not been evaluated in adolescents; safety and efficacy vytorin colesterol ezetimibe, alone or in fixed combination with simvastatin, have not been evaluated in prepubertal girls or in children younger than 10 years of age or knewin.com. Pharmacokinetic data are not available for pediatric patients younger than 10 vytorin colesterol of age.
Use of ezetimibe in combination with simvastatin has been evaluated in a limited number of adolescent boys and girls with heterozygous familial hypercholesterolemia. In a randomized, double-blind, controlled study in boys and postmenarchal vytorin colesterol 10-17 years of age with heterozygous familial hypercholesterolemia, discontinuance of therapy because of adverse effects occurred in more patients receiving ezetimibe in combination with simvastatin 10-40 mg daily 6% than in those receiving simvastatin monotherapy vytorin colesterol in addition, increases in aminotransferase or CK concentrations also occurred more frequently in patients receiving combination therapy 3 or 2% vytorin colesterol than in those receiving simvastatin monotherapy 2 or 0% respectively There vytorin colesterol no detectable adverse effects on growth or sexual maturation in adolescent vytorin colesterol or girls or on duration of menstrual cycle in girls.
Because many drugs are distributed into human milk, caution should be used if vytorin colesterol is used in nursing women; the drug should not be used in nursing women unless the potential benefits justify the possible risks to vytorin colesterol infant. There are no differences in the pharmacokinetics of ezetimibe between adolescents and adults.
No molecule (i.e., enalapril , ranitidine, metformin, and gabapentin) would be de- listed from the Formulary. Rather, certain generic version of ...:
Notice from the Executive Officer
Cholesterol medicine vytorin eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Your cholesterol medicine vytorin will not improve any faster, and the risk of serious side effects may be increased.
However, promptly talk with him or her about the risks and benefits of your higher dose. Do https://takecarehomehealth.com/vytorin-clinical-trials-1788729/vytorin-10-40 increase your dose or take this medication more often than prescribed.
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Cholesterol medicine vytorin Click the Claim Discount button to receive the reusable Vytorin coupon and lower the Vytorin cost by up to 86% at the pharmacy of your cholesterol medicine vytorin. Vytorin is a combination of two drugs, ezetimibe and simvastatin, and the quantity of each is listed in that order.
When you find a pharmacy in your area that carries this medication, but you do not have a Vytorin copay card, download a Vytorin coupon or request a discount card from the website. Ezetimibe works by reducing cholesterol absorption by the body; simvastatin is an HMG CoA reductase inhibitor.
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Ezetimibe and ezetimibe-glucuronide are highly bound cholesterol medicine vytorin to human plasma proteins. Both simvastatin and its beta hydroxyacid metabolite are highly bound approximately 95% to human plasma proteins. Relative to the fasting state, the plasma profiles of both active and total inhibitors of HMG-CoA reductase were not affected when simvastatin was administered immediately before an American Heart Association recommended low-fat meal.
|You may report side effects to Health Canada at 1-866-234-2345. cholesterol medicine vytorin||Vytorin should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver cholesterol medicine vytorin. Note that ALT may emanate from muscle, therefore ALT rising with CK may indicate myopathy see Warnings and Precautions cholesterol medicine vytorin||Cholesterol medicine vytorin "And we will be considering whether any further action is warranted in regard to Zetia or Vytorin, and also whether this study has any impact on our approach to the approval of lipid-lowering drugs. "Once we receive the final study report, we cholesterol medicine vytorin it will take as long as six months for us to fully evaluate the results of the Enhance study, he said.|
|Based on the currently available evidence, FDA has concluded that neither ezetimibe nor the fixed-combination preparation of ezetimibe and simvastatin is likely to increase vytorin colesterol risk of cancer or cancer-related deaths. respectively, of patients receiving the fixed combination vytorin colesterol ezetimibe and simvastatin and these rates were similar to those reported in patients who received simvastatin monotherapy. vytorin colesterol||Cholesterol medicine vytorin Efficacy and safety cholesterol medicine vytorin ezetimibe monotherapy in the management of primary hyperlipidemia were established in 2 multicenter, randomized, double-blind, placebo-controlled studies of 12 weeks' duration in approximately 1700 patients with primary hyperlipidemia. Ezetimibe also is used in combination with fenofibrate as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apo B, and non-HDL-cholesterol concentrations in the treatment of mixed dyslipidemia.||Vytorin colesterol for patients treated asymptomatic, vytorin colesterol associated with cholestasis, and returned to baseline after During a median follow-up period of 4.|
Mantenga la botella bien cerrada cuando no se esta vytorin colesterol. Siga las instrucciones de su m dico muy de cerca. La toronja puede interactuar con ezetimibe and simvastatin y resultar en efectos secundarios no deseados.
Guarde a temperatura ambiente fuera de la humedad y del calor. vytorin colesterol
Cholesterol medicine vytorin In 89% of the prospectively followed pregnancies, drug treatment was initiated prior to pregnancy and cholesterol medicine vytorin discontinued at some point in the first trimester when pregnancy was identified.
There are rare reports of congenital anomalies following intrauterine exposure to statins. In a review1 of approximately 100 prospectively followed pregnancies in women exposed to simvastatin or another structurally-related statin, the incidences of congenital anomalies, spontaneous abortions and fetal deaths/stillbirths did not exceed what would be expected in the general population.
Because a small amount of another drug in this class is excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women taking simvastatin should not nurse their infants. Cholesterol medicine vytorin number of cases is adequate only cholesterol medicine vytorin exclude a 3- to 4-fold increase in congenital anomalies over the background incidence.
It is not known whether simvastatin is excreted in human milk.Vytorin properties:
- Vytorin all alternative name: acotral, afordel, alcosin, alipas, alpheus, angiolip, antichol, arudel, astax, aterostat, athenil, atorvik-ez, avastin, awestatin, belmalip, bevostatin, cardin, cerclerol, cholemed, cholestad, cholestat, cholipam, christatin, colemin, colemin forte, colesken, colestop, colestricon, coracil, corexel, corsim, covastin, cynt, detrovel, ecuvas, egilipid, esvat, ethicol, extrastatin, ezentia, ezeta, ezetib, ezetim, ezetimib, ezetimibum, ezitoget, forcad, gerosim, glipal, glutasey, goldastatin, goltor, histop, hollesta, iamastatin, ifistatin, inegan, inegy, ipramid, ivast, ixacor, jabastatina, kavelor, klonastin, krustat, kymazol, labistatin, lepur, lesvatin, lip-down, lipcut, lipenil, lipexal, lipidex, lipo-off, lipoaut, lipoblock, lipociden, lipodown, lipokoban, lipola m, lipomed, lipopress, liporex, lipovatol, lipozart, lipozid, lisac, lowcholid, lumsiva, medipo, medistatin, mersivas, michol, nalecol, nezatin, nimicor, nitastin, nivelipol, normicor, normofat, nosterol, novastin, nyzoc, omistat, pantok, pantok forte, phalol, pontizoc, protecta, pulsarat, ramian, ransim, rechol, recol, redicor, redulip, redusterol, rendapid, ritec
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Simvastatin, like other inhibitors of HMG-CoA reductase, occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above 10 X ULN. Cholesterol medicine vytorin sometimes takes the form of rhabdomyolysis with or without acute renal failure secondary to myoglobinuria, and rare fatalities have occurred. The risk of myopathy is increased by high levels of HMG-CoA reductase inhibitory activity in plasma.
for VYTORIN. VYTORIN should be administered to women of childbearing age only when such patients are highly unlikely to conceive. If the patient becomes pregnant while taking this drug, VYTORIN should be discontinued immediately and the patient should be apprised of the cholesterol medicine vytorin hazard to the fetus see PRECAUTIONS, In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with ezetimibe compared with the relevant control arm placebo or HMG-CoA reductase inhibitor alone However, myopathy and rhabdomyolysis are known adverse reactions to HMG-CoA reductase inhibitors and other lipid-lowering cholesterol medicine vytorin.
In clinical trials, the incidence of CK 10 X the upper limit of normalULNwas 0.
Ecause of the risk of adverse effects to the developing vytorin colesterol, Vytorin vytorin colesterol not be administered to nursing mothers. ipitor atorvastatin and Vytorin simvastatin and ezetimibe are used to lower cholesterol levels in the blood. LiST Manual CNS vascular lesions, characterized by perivascular hemorrhage and edema, mononuclear cell infiltration of perivascular spaces, perivascular fibrin deposits and necrosis of vytorin colesterol vessels, were seen in dogs treated with simvastatin at a dose of 360 mg/kg/day, a dose that produced mean plasma drug levels that were about 14 times higher than vytorin colesterol mean plasma drug levels in humans taking 80 mg/day.
Similar CNS vascular lesions have been observed with several other vytorin colesterol of this class.
Talk to your doctor about the benefits and risks. Rarely, statins may cause or worsen diabetes. Tell your vytorin colesterol right away if you develop any of these symptoms during treatment and if vytorin colesterol symptoms last after your doctor stops this drug: muscle pain/tenderness/weakness especially with fever or unusual tiredness signs of kidney problems such as change in vytorin colesterol amount of urine This medication may rarely cause liver problems.
This drug may rarely cause vytorin colesterol problems which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy Females, older adults, and Chinese people may be at higher risk. If these rare effects occur, talk to your doctor. A very small number of people taking simvastatin vytorin colesterol have mild memory problems or confusion.
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What is the generic for vytorin?
In these studies, patients who received ezetimibe 10 mg cholesterol medicine vytorin had mean reductions of approximately 12-13% in total cholesterol, 18% in LDL-cholesterol, 15-16% in apo B, 16% in non-HDL-cholesterol, and 7-9% in triglyceride concentrations; increases in high-density lipoprotein HDL cholesterol concentrations in patients receiving ezetimibe were negligible 1% In most patients with primary hyperlipidemia, maximal or near-maximal reductions in serum cholesterol medicine vytorin and apolipoprotein concentrations are achieved within 2 weeks and maintained during continued therapy.
Data from several multicenter, randomized, double-blind, placebo-controlled studies indicate that concomitant therapy with ezetimibe and a statin may produce additive antilipemic effects. Efficacy and safety of ezetimibe monotherapy in cholesterol medicine vytorin management of primary hyperlipidemia were established in 2 multicenter, randomized, double-blind, placebo-controlled studies of 12 weeks' duration in approximately 1700 patients with primary hyperlipidemia.
Reductions in LDL-cholesterol concentrations appear to be consistent across age, gender, and baseline LDL-cholesterol concentrations.
What is the generic drug for vytorin?
In addition, VYTORIN raises levels of HDL good cholesterol medicine vytorin. It is used for patients who cannot control their cholesterol levels by diet alone. VYTORIN contains two cholesterol-lowering medications, ezetimibe and simvastatin, available as a tablet in four strengths: VYTORIN is a medicine used to lower levels of total cholesterol, LDL bad cholesterol, and fatty substances called triglycerides in the blood.
Only your doctor can determine if VYTORIN is right for you.
Is vytorin still on the market?
Inhibition of HMG-CoA reductase is a basis for an assay in pharmacokinetic studies of the -hydroxyacid metabolites active inhibitors and, following base hydrolysis, active plus latent cholesterol medicine vytorin total inhibitors in plasma following administration of cholesterol medicine vytorin. The major active metabolites of simvastatin present in human plasma are the -hydroxyacid of simvastatin and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives.
Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding -hydroxyacid, a potent inhibitor of HMG-CoA reductase. Ezetimibe was the major component in feces and accounted for 69% of the administered dose, while ezetimibe-glucuronide was the major component in urine and accounted for 9% of the administered dose.
Are there alternatives for vytorin?
In clinical studies, administration of ezetimibe, 50 mg/day to 15 healthy subjects for up to 14 days, or 40 mg/day to 18 patients with primary hypercholesterolemia for cholesterol medicine vytorin to 56 days, was generally cholesterol medicine vytorin tolerated. A few cases of overdosage have been reported; most have not been associated with adverse experiences.
In the event of an overdose, symptomatic and supportive measures should be employed. No specific treatment of overdosage with VYTORIN can be recommended.
When was vytorin recalled?
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Combination of these drugs with VYTORIN is contraindicated. Certain drugs that inhibit this vytorin colesterol pathway can raise the plasma levels of simvastatin and may increase the risk of vytorin colesterol.
These include itraconazole, ketoconazole, posaconazole, and voriconazole, the macrolide antibiotics erythromycin and clarithromycin, and the ketolide antibiotic telithromycin, HIV protease inhibitors, boceprevir, telaprevir, the antidepressant nefazodone, cobicistat-containing products, or grapefruit juice.
Does vytorin cause an increase in creatin?
In a study including 16 elderly patients between 70 and 78 years of age cholesterol medicine vytorin received simvastatin 40 mg/day, the mean plasma level of HMG-CoA reductase inhibitory activity was increased approximately 45% compared with 18 patients between 18-30 years of age.
Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces. Plasma concentrations of total radioactivity simvastatin plus 14C-metabolites peaked at 4 hours and declined rapidly to about 10% of peak by 12 hours postdose. In a multiple-dose study with ezetimibe given cholesterol medicine vytorin mg once daily for 10 days, plasma concentrations for total ezetimibe were about 2-fold higher in older 65 years healthy subjects compared to younger subjects.
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Simvastatin is a substrate for CYP3A4. Concomitant administration of medicinal products that are inhibitors of the transport protein OATP1B1 may lead to vytorin colesterol plasma concentrations of simvastatin acid and an increased risk of myopathy.
Inhibitors of CYP3A4 can raise the plasma levels of HMG-CoA reductase inhibitory activity and increase the risk vytorin colesterol myopathy. For example, cyclosporine has been shown to increase the AUC of statins; although the mechanism is not fully understood, the increase in AUC for simvastatin acid is presumably due, in part, to inhibition of CYP3A4 and/or OATP1B1.
Can vytorin cause confusion?
You may report side effects to Health Canada at 1-866-234-2345. ov/medwatch. In Canada - Call your doctor for medical advice about side vytorin colesterol.
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Muchas drogas pueden afectar ezetimibe and simvastatin, especialmente: Esta lista no est completa y muchas otras drogas pueden afectar a ezetimibe and simvastatin. D gale a su m dico acerca de todos las medicinas que usa.
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Cholesterol medicine vytorin or 2. and 2. cholesterol medicine vytorin However, results of 2 subsequent large randomized studies the Study of Heart and Renal ProtectionSHARPand the Improved Reduction of Outcomes: Vytorin Efficacy International TrialIMPROVE-IT involving a combined study population of 27, 14 patients with chronic kidney disease or acute coronary syndrome found no consistent pattern of increased cancer risk among patients receiving the fixed-combination preparation of ezetimibe and simvastatin.
In the SHARP study, cancer cholesterol medicine vytorin cancer-related mortality occurred in 9.
Vytorin colesterol microg/kg/day for inhibiting the rise in plasma cholesterol levels in monkeys. These results are consistent with ezetimibe being a potent cholesterol absorption inhibitor. Ezetimibe was found to have an Vytorin colesterol of 0. The ED values in dogs, rats, and mice were 7, 30, and 700microg/kg/day, respectively. vytorin colesterol
Vytorin colesterol Always ask your health care professional for complete information about this product and your specific health needs. This information is not individual medical advice and does not substitute for the advice of your health care professional. This combination medication is used along with a proper diet to help lower "bad" cholesterol and fats such as LDL, triglycerides and raise "good" cholesterol HDL in the blood.
This information does not assure that this product is safe, effective, or appropriate vytorin colesterol you. Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet. Vytorin colesterol HOW TO USE THIS INFORMATION: his is a summary and vytorin colesterol NOT have all possible information about this product.
-fold. but no change in AUC, for simvastatin total and active inhibitors with concomitant administration of single doses of simvastatin and propranolol. The pharmacokinetics of the enantiomers of propranolol were not affected. In a pharmacokinetic vytorin colesterol, concomitant gemfibrozil administration increased total ezetimibe concentrations approximately 1.
The clinical relevance of this finding is unclear. vytorin colesterol
Vytorin colesterol Individuals who do not meet the insurance criteria may still qualify for the Merck Patient Assistance Program if vytorin colesterol attest that they have special circumstances of financial hardship, and their income meets the program criteria. Applicable drugs: Vytorin ezetimibe-simvastatin Tablet More information please vytorin colesterol 800-727-5400 Visit Website Elligibility requirements: May have insuranceVariesFDA Approved Diagnosis - See Program Website for DetailsThe patient must also be residing in the US.
his program provides financial assistance to eligible individuals vytorin colesterol cover coinsurance, copayments, healthcare premiums vytorin colesterol deductibles for certain treatments. Elligibility requirements: Determined case by caseAt or below 400% of FPLNot specifiedMust be residing in the US or a US territory, and under the care of a US physicianAt Merck we realize that sometimes exceptions need to be made based on the patient's individual circumstances.
Also, for those who are eligible for health insurance, but cannot afford the insurance premium, the foundation may be able to help by paying some or all of the medical portion of insurance premiums. Call for most recent medications as the list is subject to change. vytorin colesterol vytorin colesterol
Vytorin colesterol All patients recovered without sequelae. The dialyzability of simvastatin and its metabolites in man is not known at present. g. vytorin colesterol
Cyclosporine concentrations should be monitored in patients receiving VYTORIN and cyclosporine. The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of VYTORIN see CLINICAL PHARMACOLOGY, The risk of myopathy/rhabdomyolysis is increased by concomitant administration of amiodarone or verapamil with higher doses of VYTORIN see WARNINGS, Concomitant cholestyramine administration decreased the mean Vytorin colesterol of total ezetimibe approximately 55% The incremental LDL-C reduction due to adding VYTORIN vytorin colesterol cholestyramine may be reduced by this interaction.
Caution should be exercised when using VYTORIN and cyclosporine concomitantly due to increased exposure to both ezetimibe vytorin colesterol cyclosporine. vytorin colesterol
Vytorin colesterol VYTORIN should be administered to women of child-bearing potential only when such vytorin colesterol are highly unlikely to conceive and have been informed of the potential hazards. In oral gavage embryo-fetal development studies of ezetimibe conducted in rats and rabbits during organogenesis, there was no evidence of embryolethal effects at the doses vytorin colesterol.
As safety in pregnant women has not been established, treatment should be immediately discontinued as soon as pregnancy is recognized.
Cholesterol medicine vytorin If you are a woman of childbearing age, you should use an effective method of birth control to cholesterol medicine vytorin pregnancy while using VYTORIN.
See the end of this leaflet for a complete list of ingredients in VYTORIN. are pregnant or plan to become pregnant. VYTORIN may harm your unborn baby.